Before Bakewell

Before After Before After

The Development, Characterisation and Application of an OATP1B1 Inhibition Assay in Drug Discovery

Department of Discovery DMPK AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire UK (MI, PB); Department of Medicinal Chemistry AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire UK (RJR); Department of Bioscience AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicestershire UK (RJ); Metabolism and Pharmacokinetics, Bristol-Myers Squibb, 5 Researc...

Instructions Before

Before Inflation

Observations of the cosmic microwave sky are revealing the primordial nonuniformities from which all structure in the Universe grew. The only known physical mechanism for generating the inhomogeneities we see involves the amplification of quantum fluctuations during a period of inflation. Developing the theory further will require progress in quantum cosmology, connecting inflation to a theory ...

Before Clarity

I f you're at all like me, you've spent a lot of time thinking about what makes " good design " good. Most software developers become preoccupied with this question at some point in their careers, usually after witnessing the effects of bad design first hand. At that point, we start to reflect. We go through a stage where we feel we know what good design is but can't really define it. Then we l...